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Fig. 4 | Epigenetics & Chromatin

Fig. 4

From: The functions of SET domain bifurcated histone lysine methyltransferase 1 (SETDB1) in biological process and disease

Fig. 4

The mechanisms mediating the function of SETDB1 in tumors. SETDB1 directly inhibits or cooperates with other modulators (e.g., Smad3 and ERG) to regulate the genes-related to tumorigenesis and tumor progression. CRC colorectal cancer, EMT epithelial–mesenchymal transition, NSCLC non-small cell lung cancer, PDAC pancreatic ductal adenocarcinomas

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Epigenetics & Chromatin

ISSN: 1756-8935