Skip to main content
Fig. 5 | Epigenetics & Chromatin

Fig. 5

From: The functions of SET domain bifurcated histone lysine methyltransferase 1 (SETDB1) in biological process and disease

Fig. 5

The role of SETDB1 in tumors by methylating nonhistones. SETDB1 trimethylates AKT at K64, K140 or K142 to increase the phosphorylation and activity of AKT, which accelerates non-small cell lung cancer and colorectal cancer or skin tumorigenesis, respectively. In liver cancer, SETDB1 dimethylates gain-of-function (GOF) mutant P53 at K370 to prevent its degradation by ubiquitination, and then promotes liver cancer cell growth

Back to article page

Epigenetics & Chromatin

ISSN: 1756-8935