Fig. 12

Hif1a locus, CTCF binding and its extensive chromatin looping in lens fiber cells. Hif1a locus including its 5’-flanking genomic regions is highlighted in yellow. Lens fiber cell chromatin looping patterns shows marked differences compared to lens epithelium. Two candidate upstream enhancers are boxed in the H3K27ac, H3K4me1 and ATAC-seq tracks. Specific CTCF peaks and loops discussed in the text are marked by numbered arrows and dotted boxes (1–10) and L1-L10, respectively. See Fig. 10 for individual track description