Fig. 13

CTCF-binding, RNA polymerase II and other features of the Cryaa locus. The Cryaa locus including its 5’- and 3’-flanking genomic regions is highlighted in yellow and resides outside of large looping systems. Note two flanking upstream and downstream ~ 140 kb (T1) and ~ 160 kb (T2) TADs, respectively. Specific CTCF peaks discussed in the text are marked by numbered arrows and dotted boxes (1–3). Note an overlap between RNA polymerase II (Pol II) signal across the gene body in lens ChIP-seq and CTCF in fiber cell chromatin. See Fig. 10 for individual track description