Fig. 14

Limited large loop patterns, CTCF binding and other features of the γ-crystallin cluster. The γ-crystallin cluster occupies over 70 kb of DNA (yellow box) and is marked by high RNA polymerase II (Pol II) consecutive domains at the Cryga, Crygb, Crygc, Crygd, and Cryge loci in lens chromatin. Three CTCF peaks shared by lens epithelium and fibers are marked dotted boxes (1–3). Note increased CTCF broad binding corresponding to RNA polymerase II presence in lens chromatin. No proximal large loops are found through the entire γ-crystallin cluster in both lens chromatins. See Fig. 10 for individual track description