Fig. 15

Large loop patterns, CTCF binding, RNA polymerase II, and other features of the Crybb2-Crybb3 locus. Both gene bodies are located between ~ 70 kb upstream and ~ 110 kb long downstream TADs. Similar to the γ-crystallin cluster, no proximal large loop interactions were detected within these loci. Consistent with RNA-seq data [58], the Crybb3 shows higher Pol II signal compared to the adjacent Crybb2 locus. Multiple CTCF peaks are found upstream of the Crybb3 locus (boxes 1–3). A large domain of CTCF overlaps with Pol II at the Crybb3 gene. See Fig. 10 for individual track description