Fig. 8

CTCF binding in lens epithelium and fibers and ES cells, role of DNA methylation and different CTCF-anchored looping distributions. (a) Two comparisons between total number of peaks identified in lens epithelium and fiber cells with 11,947of sheared CTCF peaks. (b) Identification of the top enriched motifs with the peaks and their direct comparison with known CTCF binding motifs. (c) CTCF peaks and DNA methylation (epi, fiber, and ES cells) in lens epithelium-specific, fiber-specific and shared peaks. Shown are centers of the peaks and their 5 kb flanking regions. (d) Proportions of loops anchored by CTCF. Three possible loop-CTCF anchor arrangements are shown. Note gain of total numbers of peaks with one or two anchors in lens fiber cells