Table 1 The confirmed post-translational modifications in human UHRF1
From: Roles of post-translational modifications of UHRF1 in cancer
Site on UHRF1 protein | Location in UHRF1 structure | Type of PTM | Team |
|---|---|---|---|
S652 | Linker 4 | Phosphorylation | Honghui Ma et al. [28] |
S298 | Linker 2 | Phosphorylation | Satomi Kori et al. [32] |
S311 | PHD | Phosphorylation | J Yang et al. [30] |
S105-109 | Linker 1 | Phosphorylation | Hao Chen et al. [29] |
S674 | Linker 4 | Phosphorylation | Haoxing Zhang et al. [38] |
S265 | TTD | Phosphorylation | Yuchong Peng et al. [39] |
T210 | TTD | Phosphorylation | Yongming Fu et al. [31] |
K60, K644, K646, K648 | UBL, Linker 4 | Acetylation | Ye Joo Hong et al. [43] |
K490 | SRA | Acetylation | Ja Young Hahm et al. [40] |
K670 | Linker 4 | Acetylation | Linsheng Wang et al. [42] |
K385 | Linker 3 | Methylation | Ja Young Hahm et al. [44] |
K385、K500 | Linker 3, SRA | Methylation | Huifang Zhang et al. [45] |
K500 | SRA | Ubiquitylation | Huifang Zhang et al. [45] |
/ | RING | Ubiquitylation | Abdulkhaleg Ibrahim et al. [51] |
600–687 | Linker 4 | Deubiquitination | Honghui Ma et al. [28] |
K659 | Linker 4 | Deubiquitination | Zhi-Min Zhang et al. [59] |