Fig. 1

Identification of TFs associated with TCOF1 SE. (A) Schematic diagram showing the workflow for DNA pull-down assay. (B) Diagram depicting the bioinformatics prediction of associated TFs. (C) Venn diagram shows TFs potentially binding to the TCOF1-E1 SE identified by bioinformatics analysis and mass spectrometry. The size of TFs uniquely found by bioinformatics prediction was proportionate to -log10 transformed p-value, and the size of TFs found by mass spectrometry only was in proportion to -log10 transformed BH-adjusted p-value. The box in blue represents the factors that were only predicted by bioinformatics. The box in yellow represents the factors that were only identified by mass spectrometry. The box in green represents the factors that were identified by both bioinformatics and mass spectrometry. (D) TF DNA motif analysis at TCOF1-E1 SE. The bar chart shows the score of enriched motif occurrence identified at TCOF1-E1 SE. (E) The overall survival curves of FOSL2 and FOSL1 in TNBC patients