Fig. 2
From: Tissue-specific roles of de novo DNA methyltransferases
DNMT3A plays pivotal role in germ cell maturation and during preimplantation. Dnmt3a knockout primordial germ cells (PGC) are unable to differentiate to mature germ cells and can not establish parental-specific methylation patterns required for genomic imprinting. The PGCs maintain their ability to replicate and remain PGCs. DNMT3B plays minor role in complementing of the maintainance methylation activity of DNMT1 in mouse embryonic fibroblasts (MEF). ICRs are imprinting control regions. Lollipops represent CpG sites. Black CpGs are methylated, white CpGs are unmethylated