Fig. 3
From: Tissue-specific roles of de novo DNA methyltransferases
DNMT3A and DNMT3B are involved in fetal development. DNMT3B is required for the decidualization of the endometrium and the absence of the gene from progesterone-sensitive cells disturbs this process and leads to embryonic loss. Both DNMT3A and DNMT3B are required for labyrinth formation. The maintenance of Dnmt3b expression in trophoblast cells is crucial for embryonic development and survival