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Fig. 1 | Epigenetics & Chromatin

Fig. 1

From: Assessment of relationships between epigenetic age acceleration and multiple sclerosis: a bidirectional mendelian randomization study

Fig. 1

The process of present Mendelian randomization (MR) analyses is shown in flow chart

Assumption 1: The instrumental variables (IVs) selected for this study should demonstrate a significant association with epigenetic age. Assumption 2: The IVs chosen for present study are required to have no significant associations with other potential confounding factors. Assumption 3: The IVs utilized in present study do not have any independent causal pathways leading to multiple sclerosis other than through epigenetic age acceleration

Abbreviations: IV, instrumental variable; SNPs, single-nucleotide polymorphisms; MR, Mendelian randomization

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Epigenetics & Chromatin

ISSN: 1756-8935