Assessment of relationships between epigenetic age acceleration and multiple sclerosis: a bidirectional mendelian randomization study

Table 1 The heterogeneity and pleiotropy analysis of the MR study on epigenetic age acceleration and multiple sclerosis

Exposure	Outcome	Method	Heterogeneity		Horizontal pleiotropy		MR PRESSO
Exposure	Outcome	Method	Q	Q_p-value	MRE intercept	p-value	Qutliers	p-value
GrimAge	Multiple sclerosis	MRE	7.378	0.194	0.082	0.121	0	0.051
		IVW	12.509	0.052
PhenoAge	Multiple sclerosis	MRE	8.406	0.298	0.002	0.924	0	0.530
		IVW	8.418	0.394
HorvathAge	Multiple sclerosis	MRE	18.689	0.067	0.029	0.555	9	0.150
		IVW	19.319	0.081
HannumAge	Multiple sclerosis	MRE	3.830	0.280	-0.017	0.757	0	0.235
		IVW	3.977	0.409
Multiple sclerosis	GrimAge	MRE	76.473	0.528	0.020	0.279	0	0.550
		IVW	77.663	0.521
Multiple sclerosis	PhenoAge	MRE	106.905	0.040	0.006	0.528	0	0.076
		IVW	107.422	0.043
Multiple sclerosis	HorvathAge	MRE	73.356	0.153	-0.008	0.462	23	0.084
		IVW	74.003	0.162
Multiple sclerosis	HannumAge	MRE	115.737	0.010	0.006	0.436	1	0.059
		IVW	116.593	0.011

Abbreviations: MR, Mendelian randomization; MRE, MR Egger; IVW, Inverse Variance Weighted, Q, Cochran’s Q test

ISSN: 1756-8935