Skip to main content
Fig. 7 | Epigenetics & Chromatin

Fig. 7

From: H3K9 post-translational modifications regulate epiblast/primitive endoderm specification in rabbit blastocysts

Fig. 7

Effect of class I HDAC inhibition on the transcriptome of rabbit embryos. (A) Heatmap illustrating differentially expressed genes among EPI, PE and TE groups. (B) Two-dimensional UMAP representation of samples, color-coded according to embryonic lineage. (C) Two-dimensional UMAP representation of samples color-coded by both lineage and culture condition. (D-F) Heatmap of differentially expressed genes between control samples and those treated with 2 µM UF010 for 48 h within the EPI (D), TE (E), and PE (F) lineage. In panels A, D, E and F, expression is shown in log2Ex scaled and log-normalized format. (G) The protein-protein interaction (PPI) network displays differentially expressed genes (DEGs) as seed nodes in blue and their top 10 ranking neighbors in grey for each cell lineage. Statistically significant correlations between DEGs are depicted as edges (grey lines). This analysis was conducted separately for downregulated and upregulated genes

Back to article page

Epigenetics & Chromatin

ISSN: 1756-8935