Fig. 1

Schematic diagram showing post-translational modifications in TIP60. (A) The domain map illustrates TIP60’s various domains and the post-translational modifications associated with them (amino acid numbering is as per isoform 2). The different domains are CD (chromodomain), IDR (intrinsically disordered region), HAT domain (histone acetyltransferaese), and NR box (nuclear receptor) motif. Yellow color circle depicts acetylation, blue color circle represents phosphorylation, purple color quadrilateral shows glycosylation, pentagon represents methylation, dark blue octagon represents SUMOylation, and green rectangle represents ubiquitination modification. Note- Ubiquitination sites are yet not well charecterized. (B) The domain map of TIP60 isoforms 1, 2, and 3. Isoform 1 has an intron region of 33 amino acid, while isoform 2 and 3 lacks this intron region. Isoform 3 is also devoid of exon 5 (52 amino acid). Dash line depicts missing regions in the respective isoform