Table 1 The regulatory factors and substrate modification sites for histone and nonhistone Kcr

Writer

p300

H3K18

/

[20]

CBP

H3K18

NPM1, DDX5, ENO1

[12, 20, 90]

MOF

H3K4, H3K9,

NPM1

[12, 22]

H3K18, H3K23,

H4K8, H4K12

GCN5

H3K9, H3K14,

/

[25]

H3K18, H3K23,

H3K27

HAT1*

H3K9

/

[48]

Rtt109*

H3K9

/

[48]

yeast Esa1*

H4K5, H4K8,H4K12, H4K16

/

[25]

PCAF

/

NPM1, DDX5

[12, 22]

HBO1

H3K14, H4K12

CANX(K525)

[26, 28]

TIP60

/

EB1

[29]

Eraser

SIRT1

H3K9, H4K8,

SERCA2a(K120)

[32, 38, 39, 78]

H3K4, H3K18,

H2AK119

SIRT2

H3K9

ENO1(K420)

[38, 90]

SIRT3

H3K4, H3K27

PRKACA

[40, 91]

FOSIR5*

H3K18

/

[41]

SIRT6

H3K27

ACSL5(K98/361/367)

[42]

SIRT7

/

PHF5A(K25)

[43]

HDAC1

H3K4, H3K9,

NPM1

[12, 35]

H3K23, H4K8,

H4K12, H3K18

HDAC2

H3K9, H3K23,

/

[32, 33]

H4K8, H4K12,

H3K18, H2BK12

HDAC3

H3K9, H4K8, H3K18

NPM1, AKT1

[12, 32, 35]

HDAC6

/

Lamin A (K265/270)

[36]

HDAC7

/

14–3–3ε (K73/78)

[37]

HDAC8

H3K4, H3K9,

/

[32, 33]

H3K23, H4K8,

H4K12, H3K18

Reader

TAF14

H3K9

/

[48]

YEATS2

H3K27

/

[45]

AF9

H3K9, H3K18,

/

[46]

H3K27

MOZ, DPF2

H3K14

/

[11]

TAF1

H3K9, H3K27

/

[46]

Other regulators

NEAT1

H3K27

/

[53]

CDYL

H2BK12, H3K9,

RPA1

[13, 15]

H3K27, H4K8,

H3K18, H3K23,

H3K79

ACSS2

H3K9, H3K18

/

[20, 110]

ACOX1

/

/

[10]

ACOX2

H2BK86

Ehhadh (K329/344/572)

[19]

Crot (K69/384)

ACOX3

/

/

[10]

ACADS

/

/

[10]

GCDH

/

/

[50]

ECHS1

H3K18, H2BK12

/

[76]

EPB41L4AAS

H3K27

/

[116]

BRD4

H3K18

/

[101]