Fig. 6

Identifying pathogenic cell types for epigenetics and Chromatin Dynamics of lung fibrosis. (A) The UMAP plot illustrates the distribution of cells under two distinct conditions: saline and BLM. The blue dots represent cells treated with saline, while the orange dots indicate those treated with BLM. (B) The UMAP plot of various cell types, each represented by distinct colors. The legend on the right side lists these cell types and their corresponding color codes. (C) Violin plot shows the expression levels of the identified marker genes relative to each other. (D) Bubble plot reveals how 14 specific genes are expressed across various cell types, based on mouse single-cell RNA sequencing information. (E) Bubble plot shows a visual representation of how 14 genes are expressed in different cell types, as documented in the human lung cell atlas. The arrangement features cell types along the rows and genes along the columns. The bubble size is proportional to the number of cells expressing the gene, and the color gradient indicates the degree of gene expression. The UMAP plot showing cell specificity of PBX (F), LIFR (G) and IL7R (H) expression in human and mouse