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Fig. 6 | Epigenetics & Chromatin

Fig. 6

From: H3F3A K27M mutations drive a repressive transcriptome by modulating chromatin accessibility independent of H3K27me3 in Diffuse Midline Glioma

Fig. 6

K27M-Driven Regulatory Effects on Tumor Suppressor Genes & Oncogenes. (A) Heatmap displaying differential expression of known oncogenes and tumor suppressor genes from the Cancer Gene Census Tier 1 (as retrieved from Cosmic) in K27M and PRC2 mutant cell lines relative to their isogenic wild-type counterparts. The heatmap illustrates log2 fold change (log2FC) values, with red indicating upregulation and blue indicating downregulation in the mutants. Genes included in this figure were stringently selected for a log2FC greater than 1.5. Cells marked with zero indicate absence of data for a given gene in one of the mutation types, replacing non-available (NA) entries for clearer visual representation. This heatmap highlights the oncogenes and tumor suppressor genes most significantly influenced by the mutations

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Epigenetics & Chromatin

ISSN: 1756-8935