Fig. 5
From: LSD1 induces H3 K9 demethylation to promote adipogenesis in thyroid-associated ophthalmopathy
The combination of LSD1 inhibitor and clinical drugs can effectively reduce the adipogenesis in TAO cells. Representative images of oil red staining of lipid droplets in TAO cells treatment with DMSO, Teprotumumab (T), Pargyline (P), Teprotumumab + Pargyline(T + P) (A), scale bar: 20 μm. Quantitative analysis of the number of lipid droplets in A (B). *p < 0.05, **p < 0.01, ***p < 0.001 according to the Two-way ANOVA, n = 6 biological repeats. Expression of adipose differentiation genes and Inflammatory factor in TAO cells treatment with DMSO, Teprotumumab (T), Pargyline (P), Teprotumumab + Pargyline(T + P) (C–I). *p < 0.05, **p < 0.01, ***p < 0.001 according to the two-way ANOVA test, n = 3 biological repeats