Table 1 Signaling pathway and target genes of SWI/SNF subunits

SMARCA2(BRM)

BAF190B

CBAF, PBAF, NCBAF

Thyroid cancer

PAX8 和 FOXE1

[106]

SMARCA4 (BRG1)

BAF190A

CBAF, PBAF, NCBAF

Lung cancer, endometrial cancer, glioma, breast cancer, ovarian cancer

HIF2A, GLUT1, TGFB2 和 SOX2

[12, 99, 100, 107, 108]

SMARCB1

BAF47,

SNF

CBAF, PBAF

Rhabdomyoid tumors, colorectal cancer and pancreatic cancer

Wnt/β-catenin signaling Pathways

[22, 77, 93]

PBRM1

BAF180

PBAF

Colorectal cancer (CRC), prostate cancer, kidney cancer

WNT and PI3K/AKT signaling pathways

ATM, ARID1A and TP53 Chromosome stability related genes APC and KRAS.

PD-L1 and cGAS/STING pathway related genes

[86, 88, 109]

GLTSCR1

BICRA

NcBAF

Colorectal cancer (CRC),

Regulation of alternative splicing of ZO1

[110]

ARID1A

BAF250A

CBAF

Ovarian clear cell cancer, endometrial cancer, breast cancer, neuroblastoma, non-small cell lung cancer, colorectal cancer, prostate cancer,

CXCR2 signaling pathway,

p21, CDK13, HERVH, FOXA1, BRD4,

[8, 9, 45, 79, 84, 111,112,113]

ARID1B

BAF250B

CBAF

Neuroblastoma, liver cancer, lung cancer, endometrial cancer

Wnt/β-catenin signaling Pathways

NEAT1

[6, 41, 78, 114,115,116,117]

ARID2

PBAF

Hepatocellular carcinoma, non-small cell lung cancer

HSPA1A

BRD7

PBAF

Breast cancer, prostate cancer, non-small cell lung cancer

YB1 (Y-box-binding protein-1) inhibition, AR signaling Pathways, PRC2 and NuRD complex, p53

[63, 64, 118,119,120,121]

BRD9

NcBAF

Pancreatic cancer, acute myeloid leukemia, multiple myeloma, gastric cancer

TGFβ/Activin-SMAD2/3 signaling pathway TUFT1/AKT/GSK-3β signal axis,

MYC, RRS1, PES1, and BOP1

SOX4, PROM1 (CD133), SNAI2, SMAD1

[65, 67,68,69, 122]