Table 2 The SWI/SNF complex in macrophages and T cells
From: Chromatin remodeling and cancer: the critical influence of the SWI/SNF complex
Subunit Name | Immune Cells | Anti-Tumor Immune Signaling Pathway/Target Gene | Associated Cancer | Relevant Drugs/Inhibitors | References |
|---|---|---|---|---|---|
MATR3 | CD4 + T cells | Epigenetic Regulation, TOX | Hepatocellular Carcinoma | Epigenetic Modulators | [125] |
PBRM1 ARID2 | CD8Tcell | IFN-γ, mTORC1 | Melanoma | æ— | [44] |
SMARCB1 | CD8 + T cells | LSD1 | Ovarian Cancer | SP-2577 | [103] |
BRD9 | Macrophages | IFN, STAT1,STAT2,IRF9 | Various Cancers | BRD9 inhibitors (I-BRD9, BI-9564), Dexamethasone | [122] |
DPF2 | Macrophages | NRF2-dependent anti-inflammatory pathways | Hematopoietic Cancers, | NRF2 activators | [126] |