Table 3 The SWI/SNF complex in DNA repair
From: Chromatin remodeling and cancer: the critical influence of the SWI/SNF complex
Subunit | DNA repair pathway | Signaling Pathway/Target Gene, | Associated Cancer, | DNA Damage Type | References. |
|---|---|---|---|---|---|
ARID1A | NHEJ, HR | RAD21, CTCF, HDAC1-RSF1 | osteosarcoma, breast cancer | DSBs | [75] |
ARID1A/B, BRG1 | HR | Promotes end resection of DNA to facilitate RAD51 binding to DNA to promote HR. | Osteosarcoma-U2OS, colon cancer-HCT116 | DSBs | [128] |
SWI/SNF | HR | RPA, ATR | Lymphoblastic Lymphoma | DSBs | [129] |
ARID1a | HR | P53BP1, PARP1 | cervical cancer | DSBs | [130] |
ARID2 | HR, NHEJ | BRCA1, RAD51, 53BP1 | Hepatocellular Carcinoma | DSBs | [131] |