Fig. 3

Differentially methylated regions distinguish infants with severe infection from those with mild to moderate symptoms. Top panel: DMR plot for the two most significant DMRs within the A ZBTB38 and B TRIM6-TRIM34 genes. DNA methylation patterns in severe and mild/moderate samples differed for most of the CpGs in the DMRs. In the figure, some beta value dots of the CpGs that constitute the DMRs overlap in the two groups with similar values. Bottom panel: pairwise correlation between CpG sites in DMRs in A ZBTB38 and B TRIM6-TRIM34 genes