Fig. 4

DNA methylation levels of DMPs within ZBTB38 in RSV and HC cohorts. Boxplots showing DNA methylation levels at five DMPs within ZBTB38 for the RSV cohort compared to the HC cohort from GEO. The HC cohort includes samples collected from children at three-time points: birth, 12 months, and 60 months. The RSV cohort is represented by children with mild to moderate symptoms. Methylation levels at birth are similar to the methylation levels of RSV children with mild to moderate symptoms. For all the CpGs, the HC cohort shows an increase of methylation with age, in contrast to the RSV cohort, where hypomethylation is observed for children severely ill