DNA methylation signatures of severe RSV infection in infants: evidence from non-invasive saliva samples

Table 2 Cluster of differentially methylated positions (DMPs) within the TRIM6-TRIM34 and ZBTB38 genes

CpGs	Position	Gene name	Gene group	Delta beta	P-value
cg14304349^*1,2	chr11: 5617812	TRIM6-TRIM34	TSS200; 5’UTR	0.13	8.41 × 10^–04
cg15137954^*1,2	chr11: 5618023	TRIM6-TRIM34	1^stExon; 5’UTR	0.11	4.53 × 10^–05
cg22133704^*1,2	chr11: 5617926	TRIM6-TRIM34	1^stExon; 5’UTR	0.11	2.53 × 10^–04
cg23371833	chr3: 141133836	ZBTB38	5’UTR	0.17	7.40 × 10^–03
cg23967605	chr3: 141105198	ZBTB38	5’UTR	0.20	7.18 × 10^–03
cg03183447^*1,2	chr3: 141105876	ZBTB38	5’UTR	0.22	1.25 × 10^–03
cg10394922^*1,2	chr3: 141106189	ZBTB38	5’UTR	0.26	1.08 × 10^–03
cg17356452^*1	chr3: 141105920	ZBTB38	5’UTR	0.27	1.18 × 10^–03
cg00527195	chr3: 141105273	ZBTB38	5’UTR	0.29	6.55 × 10^–03
cg25395158^*1	chr3: 141105014	ZBTB38	5’UTR	0.31	1.27 × 10^–03

Delta Beta refers to the comparison of mild/moderate vs. severe patient groups
^*1DMPs after adjusting the model for age and previous episodes of bronchiolitis
^*2DMPs excluding children with previous episodes of bronchiolitis

ISSN: 1756-8935