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Table 3 Differentially methylated regions (DMRs) associated with RSV severity

From: DNA methylation signatures of severe RSV infection in infants: evidence from non-invasive saliva samples

Position

Overlapping genes

n CpGs

Delta beta

FDR

chr2:47261254–47262234

TTC7A

3

0.15

3.19 × 10–06

chr3:192289245–192289293

FGF12

3

0.12

9.27 × 10–04

chr5:178576749–178577542

ADAMTS2

3

0.12

3.70 × 10–03

chr19:41385865–41386507

CTC-490E21.12, CYP2A7

3

0.16

1.05 × 10–05

chr1:149162219–149162518

 

4

0.12

4.90 × 10–03

chr2:91932642–91933195

AC027612.4

4

0.12

5.96 × 10–03

chr17:27456682–27456844

MYO18A

4

0.16

2.06 × 10–04

chr4:674399–675936

MYL5, MFSD7

5

−0.16

2.58 × 10–04

chr15:77816887–77818281

RP11-307C19.1

5

−0.11

2.09 × 10–04

chr2:113990230–113995456

PAX8-AS1, PAX8

16

0.11

3.91 × 10–03

chr11:5616177–5618408

TRIM6-TRIM34, HBG2, AC015691.13

11

−0.11

2.83 × 10–24

chr2:162099304–162101506

AC009299.3, AC009299.2

7

0.12

1.16 × 10–07

chr11:60414241–60414918

LINC00301

7

0.10

6.38 × 10–06

chr1:149144161–149148312

RNU1-114P

18

0.12

2.18 × 10–08

chr3:141102599–141107482

ZBTB38

15

−0.14

1.93 × 10–11

chr16:49732224–49733377

ZNF423

6

−0.10

1.25 × 10–04

  1. The top statistically significant regions are marked in bold. Delta Beta refers to the comparison of mild/moderate vs. severe patient groups. FDR: means here ‘minimum smoother FDR’