DNA methylation signatures of severe RSV infection in infants: evidence from non-invasive saliva samples

Table 5 Differential methylation analysis by bisulfite pyrosequencing for each cohort of the study

Gene—position	Discovery cohort (n = 14)				Validation cohort (n = 16)				Total (n = 30)
	P-value		Delta beta		P-value		Delta beta		P-value	Delta Beta
	R1	R2	R1	R2	R1	R2	R1	R2
ZBTB38 cg00527195	2.36 × 10^–05	7.72 × 10^–06	−0.37	−0.37	0.02	0.04	−0.22	−0.19	2.89 × 10^–11	−0.29
ZBTB38 cg03183447	1.31 × 10^–04	1.57 × 10^–04	−0.28	−0.28	5.70 × 10⁻⁰³	4.65 × 10⁻⁰³	−0.18	−0.19	1.29 × 10^–12	−0.23
ZBTB38 cg10394922	7.25 × 10^–05	1.07 × 10^–04	−0.33	−0.33	3.71 × 10⁻⁰³	5.10 × 10⁻⁰³	−0.20	−0.19	1.23 × 10^–12	−0.26
ZBTB38 cg17356452	1.11 × 10^–05	1.31 × 10⁻⁰⁵	−0.36	−0.36	0.04	0.04	−0.18	−0.17	8.90 × 10^–11	−0.27
ZBTB38 cg23371833	7.90 × 10^–06	1.31 × 10^–06	−0.17	−0.16	0.06	0.05	−0.10	−0.10	9.32 × 10^–10	−0.13
ZBTB38 cg23967605	7.82 × 10⁻⁰⁵	5.89 × 10^–05	−0.36	−0.36	8.40 × 10^–03	7.91 × 10^–03	−0.21	−0.22	3.36 × 10^–12	−0.28
ZBTB38 cg25395158	1.85 × 10⁻⁰⁴	1.66 × 10⁻⁰⁴	−0.35	−0.35	0.01	0.01	−0.20	−0.20	2.98 × 10^–11	−0.27
TRIM6-TRIM34 cg22133704	2.77 × 10^–02	2.41 × 10^–02	−0.11	−0.11	0.32	0.40	−0.03	−0.03	7.04 × 10^–04	−0.07
TRIM6-TRIM34 cg15137954	3.55 × 10^–02	4.38 × 10^–02	−0.12	−0.12	0.36	0.34	−0.04	−0.04	1.16 × 10^–03	−0.08
TRIM6-TRIM34 cg14304349	4.94 × 10^–02	7.56 × 10^–02	−0.09	−0.07	0.47	0.37	−0.01	−0.01	4.66 × 10^–03	−0.04

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